Gene Therapy

* This product is for research use only. Not intended for use in the treatment or diagnosis of disease.

Concept of Gene Therapy

Gene therapy is a biomedical technique in which a normal or therapeutic exogenous gene is inserted into a target cell to repair a defective gene or to replace a defective gene to treat a disease.

The narrow concept refers to the replacement or addition of a defective gene in a patient's body with a gene that has a normal function for treatment.

The broader concept refers to the transfer of certain genetic material into the patient's body so that it is expressed in the patient's body, ultimately resulting in the treatment of a disease.

With the understanding of the mechanism of action of genetic material, we began to consider how to artificially intervene in the process of inheritance and expression. Based on the development of genetic technology, we began to modify and modify genes at the molecular level.

Conventional treatment is generally aimed at various symptoms caused by genetic abnormalities, which can be said to treat the symptoms rather than the root causes, while gene therapy is aimed at the root cause of genetic diseases - the abnormal genes themselves. Gene abnormalities are the essence of genetic diseases, as long as the abnormal genes are treated. Corrected, or replaced the defective gene with the normal gene, then the external symptoms will also be solved.

Gene Therapy

Classification of Gene Therapy

  • According to the target cells
    • Germ cell gene therapy
    • Somatic cell gene therapy
      Broadly speaking, germ cell gene therapy targets sperm, eggs and early embryonic cells. Somatic cell therapy is limited to localized cells of the individual. Due to the current immaturity of gene therapy technology and the limited knowledge of genes, it is not known whether the knockout or addition of a gene will result in compromised expression beyond the therapeutic target. In addition, gene modification of germ cells can be passed on to offspring and may even affect the gene pool of the entire human race, as well as involving a range of ethical issues, gene therapy is limited to somatic cells and germ cell gene therapy remains off-limits.
  • According to the route of administration
    • ex vivo
      It refers to the introduction of a vector containing exogenous genes into the human body's own or allogeneic cells (or xenogeneic cells) in vitro, and after cell expansion in vitro, it is returned to the human body. This approach is relatively classic and safe, and the effect is easier to control, but it has many steps, complex technology, high difficulty, and is not easy to popularize.
    • in vivo
      It is the assembly of an exogenous gene in a specific eukaryotic expression vector and its direct introduction into the body. This vector can be viral or non-viral, or even naked DNA. This route is simple and easy to promote, but it is not yet mature and has several problems such as short duration of efficacy, immune rejection and safety.

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Our Products

ProductsDescription
DNA Transfection KitsOur products can safely and effectively deliver plasmid DNA and virus DNA into mammalian cells, so that you can get more reliable results in your studies.
In Vivo Transfection ReagentHigh efficiency, low toxicity transfection reagent for DNA, siRNA, mRNA, and other oligonucleotides.
Protein Transfection KitsUsed to directly transfect the protein itself into mammalian cells, instead of transfecting DNA or mRNA encoding the protein of interest.
Cell Line Transfection KitsBOC Sciences provides a variety of validated cell line transfection reagents for the field of life science research to meet the transfection requirements of different types of cell lines.
RNA Transfection KitsBOC Sciences provides proven various types of RNA transfection reagents for life science research to meet different transfection requirements.
Electroporation ProductsElectroporation, as an increasingly popular physical transfection method, uses high voltage to introduce exogenous nucleic acids into many types of cells (including bacteria and mammalian cells).

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